Impact of Cadmium Exposure during Pregnancy on Hepatic Glucocorticoid Receptor Methylation and Expression in Rat Fetus
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چکیده
منابع مشابه
Impact of Cadmium Exposure during Pregnancy on Hepatic Glucocorticoid Receptor Methylation and Expression in Rat Fetus
Adverse fetal environment due to maternal undernutrition or exposure to environmental chemicals alters glucocorticoid (GC) metabolism increasing the risk of metabolic disorders in adulthood. In this study, we investigated the effects of maternal exposure to cadmium (Cd, 50 ppm) during pregnancy in the methylation of fetal hepatic glucocorticoid receptor promoter (GR) and the correlation with it...
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RNA and protein synthesis in different organs of rat offspring after chronic cadmium exposure during pregnancy.
Despite binding by placental metallothionein, cadmium (Cd) relatively easily enters fetal circulation and may be harmful to tissues and organs of offspring. Although Cd toxicology is relatively well described in the literature there are only few studies on Cd toxicity exerted during fetal life. We examined the influence of cadmium exposure during pregnancy on RNA and protein synthesis in differ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0044139